Article
HNF-1 regulates the liver-specific transcription of the chipmunk HP-20 gene.
Gene - 17 Oct 2001
Ono M, Hosoe Y, Azuma S, Shoji M, Nara K, Kondo N, Shiba T, Takamatsu N
Abstract excerpt
The chipmunk hibernation-specific protein HP-20 is a component of the 140 kDa complex that drastically decreases in the blood during hibernation, and its gene is expressed specifically in the liver. To reveal molecular mechanisms underlying the liver-specific transcription of the HP-20 gene, we isolated chipmunk HP-20 genomic clones. The HP-20 gene spans approximately 6 kb, and consists of three exons. The...
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