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Article

Distinct Melanogenic Response of Human Melanocytes in Mono‐culture, in Co‐Culture with Keratinocytes and in Reconstructed Epidermis, to UV Exposure

1 Oct 2001

Abstract excerpt

Striking differences are observed in the melanogenic response of normal human melanocytes to UVA and UVB irradiation depending on culture conditions and the presence of keratinocytes. Exposure of melanocytes co-cultured with keratinocytes to UVB irradiation triggered, already at low doses (5 mJ/cm2), an increase in melanin synthesis whereas in melanocyte mono-cultures, UVB doses up to 50 mJ/cm2 had no melanogenic...

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PMID: 11601656
DOI: 10.1034/j.1600-0749.2001.140506.x

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