Article
Leptin does not play a major role in platelet aggregation in obesity and leptin deficiency.
Obesity research - 1 Oct 2001
Ozata M, Avcu F, Durmus O, Yilmaz I, Ozdemir I C, Yalcin A
Abstract excerpt
OBJECTIVE: A recent study suggested that high concentrations of leptin enhance platelet aggregations. Therefore, the aim of this study was to investigate whether platelet aggregation is altered in patients with leptin gene mutations compared with obese subjects or controls. RESEARCH METHODS AND PROCEDURES: Four men (one homozygous man and his three heterozygous brothers) carrying a leptin gene mutation; 20...
Topics
- Adenosine Diphosphate
- Adolescent
- Adult
- Blood Platelets
- Collagen
- Epinephrine
- Heterozygote
- Homozygote
- Humans
- Leptin
- Male
- Mutation