Article
Family-based transmission disequilibrium test (TDT) and case-control association studies reveal surfactant protein A (SP-A) susceptibility alleles for respiratory distress syndrome (RDS) and possible race differences.
Clinical genetics - 1 Sept 2001
Floros J, Fan R, Matthews A, DiAngelo S, Luo J, Nielsen H, Dunn M, Gewolb I H, Koppe J, van Sonderen L, Farri-Kostopoulos L, Tzaki M, Rämet M, Merrill J
Abstract excerpt
A key cause of respiratory distress syndrome (RDS) in the prematurely born infant is deficiency of pulmonary surfactant, a lipoprotein complex. Both low levels of surfactant protein A (SP-A) and SP-A alleles have been associated with RDS. Using the candidate gene approach, we performed family-bas...
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