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Article

Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27.

American journal of human genetics - 1 Jul 2000

Ianakiev P, Kilpatrick M W, Toudjarska I, Basel D, Beighton P, Tsipouras P

Abstract excerpt

Split-hand/split-foot malformation (SHFM), a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals, is phenotypically analogous to the naturally...

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Share to Foot Deformities, Congenital
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10839977
DOI: 10.1086/302972
PMCID: PMC1287102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10839977-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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