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Article

Role of Cys54 in AbrB multimerization and DNA-binding activity.

FEMS microbiology letters - 25 Sept 2001

Phillips Z E, Strauch M A

Abstract excerpt

The DNA-binding, global regulatory protein AbrB from Bacillus subtilis is homotetrameric in solution. Mutation of the lone cysteine present in the protomers (C54), to either a serine, tyrosine or tryptophan, abolishes DNA-binding activity in vitro and regulatory activity in vivo. The effect of these changes is not due to abrogation of disulfide bond formation since it can be shown biochemically that none of the...

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PMID: 11583849
DOI: 10.1111/j.1574-6968.2001.tb10842.x

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