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Article

Identification of Genes Involved in the Host Response to Neurovirulent Alphavirus Infection

1 Nov 2001

Abstract excerpt

Single-amino-acid mutations in Sindbis virus proteins can convert clinically silent encephalitis into uniformly lethal disease. However, little is known about the host gene response during avirulent and virulent central nervous system (CNS) infections. To identify candidate host genes that modulate alphavirus neurovirulence, we utilized GeneChip Expression analysis to compare CNS gene expression in mice infected...

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PMID: 11581411
DOI: 10.1128/jvi.75.21.10431-10445.2001

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