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Article

Evidence for a novel role of copper-zinc superoxide dismutase in zinc metabolism.

The Journal of biological chemistry - 30 Nov 2001

Wei J P, Srinivasan C, Han H, Valentine J S, Gralla E B

Abstract excerpt

The LYS7 gene in Saccharomyces cerevisiae encodes a protein (yCCS) that delivers copper to the active site of copper-zinc superoxide dismutase (CuZn-SOD, a product of the SOD1 gene). In yeast lacking Lys7 (lys7Delta), the SOD1 polypeptide is present but inactive. Mutants lacking the SOD1 polypeptide (sod1Delta) and lys7Delta yeast show very similar phenotypes, namely poor growth in air and aerobic auxotrophies...

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Identifiers

PMID: 11581253
DOI: 10.1074/jbc.M104708200

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Evidence for a novel role of copper-zinc superoxide dismutase in zinc metabolism.PMID 11581253Read ↗

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