Article
FimH-mediated autoaggregation of Escherichia coli.
Molecular microbiology - 1 Sept 2001
Schembri M A, Christiansen G, Klemm P
Abstract excerpt
Autoaggregation is a phenomenon thought to contribute to colonization of mammalian hosts by pathogenic bacteria. Type 1 fimbriae are surface organelles of Escherichia coli that mediate d-mannose-sensitive binding to various host surfaces. This binding is conferred by the minor fimbrial component FimH. In this study, we have used random mutagenesis to identify variants of the FimH adhesin that confer the ability...
Topics
- Adhesins, Bacterial
- Adhesins, Escherichia coli
- Bacterial Adhesion
- Escherichia coli
- Fimbriae Proteins
- Fimbriae, Bacterial
- Frameshift Mutation
- Genes, Bacterial
- Humans
- Microscopy, Electron
- Mutagenesis