Article
A common hormone-sensitive lipase i6 gene polymorphism is associated with decreased human adipocyte lipolytic function.
Diabetes - 1 Oct 2001
Hoffstedt J, Arner P, Schalling M, Pedersen N L, Sengul S, Ahlberg S, Iliadou A, Lavebratt C
Abstract excerpt
Hereditary factors may be involved in the pathogenesis of type 2 diabetes. A polymorphism in the hormone-sensitive lipase (HSL) gene (HSLi6) is associated with obesity and diabetes, although it is unknown whether the polymorphism is functional and thereby influences lipolysis. We genotyped 355 apparently healthy nonobese male and female subjects for the HSLi6 polymorphism. Allele 5 was found to be the most common...
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