Article
The putative role of the hormone-sensitive lipase gene in the pathogenesis of Type II diabetes mellitus and abdominal obesity.
Diabetologia - 1 Dec 1998
Klannemark M, Orho M, Langin D, Laurell H, Holm C, Reynisdottir S, Arner P, Groop L
Abstract excerpt
Impaired lipolysis has been proposed as a pathogenic factor contributing to clustering of abdominal obesity and dyslipidaemia in Type II (non-insulin-dependent) diabetes mellitus--that is, the metabolic syndrome (MSDR). As this syndrome clusters in families, alterations in the hormone-sensitive l...
Topics
- Abdomen
- Adipose Tissue
- Adrenergic beta-Agonists
- Aged
- Alleles
- Body Constitution
- Diabetes Mellitus
- Diabetes Mellitus, Type 2
- Female
- Gene Frequency
- Humans
- Isoproterenol
- Linkage Disequilibrium
- Lipolysis
- Male
- Middle Aged
- Obesity
- Sterol Esterase