Article
Gender-related differences in proliferative responses of vascular smooth muscle cells to endothelin-1.
Endothelium : journal of endothelial cell research - 1 Jan 2001
Antoniucci D, Miller V M, Sieck G C, Fitzpatrick L A
Abstract excerpt
Endothelin-1 is an endothelium-derived factor which alters tone and proliferation of vascular smooth muscle and has been implicated in the development of atherosclerosis. Estrogen modulates production of and contractile responses to endothelin-1. Since atherosclerosis is less in estrogen-replete women compared to men, experiments were designed to determine whether or not there were gender-associated differences...
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