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Article

Structural and functional linkages between subunit interfaces in mammalian pyruvate kinase.

Journal of molecular biology - 21 Sept 2001

Wooll J O, Friesen R H, White M A, Watowich S J, Fox R O, Lee J C, Czerwinski E W

Abstract excerpt

Mammalian pyruvate kinase (PK) is a four-domain enzyme that is active as a homo-tetramer. Tissue-specific isozymes of PK exhibit distinct levels of allosteric regulation. PK expressed in muscle tissue (M1-PK) shows hyperbolic steady-state kinetics, whereas PK expressed in kidney tissue (M2-PK) displays sigmoidal kinetics. Rabbit M1 and M2-PK are isozymes whose sequences differ in only 22 out of 530 residues per...

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Identifiers

PMID: 11563914
DOI: 10.1006/jmbi.2001.4978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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