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Article

Arginine-glycine-aspartic acid motif is critical for human parechovirus 1 entry.

Journal of virology - 1 Oct 2001

Boonyakiat Y, Hughes P J, Ghazi F, Stanway G

Abstract excerpt

The human parechovirus 1 RGD motif in VP1 was studied by mutagenesis. An RGD-to-RGE change gave only revertant viruses with a restored RGD, while deletion of GD was lethal and nonrevertable. Mutations at the +1 and +2 positions had some effect on growth properties and a +1 M-to-P change was lethal. These studies indicate that the RGD motif plays a critical role in infectivity, presumably by interacting with...

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Source

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Identifiers

PMID: 11559835
DOI: 10.1128/JVI.75.20.10000-10004.2001
PMCID: PMC114574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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