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Article

The coxsackievirus A9 RGD motif is not essential for virus viability.

Journal of virology - 1 Dec 1995

Hughes P J, Horsnell C, Hyypiä T, Stanway G

Abstract excerpt

An RGD (arginine-glycine-aspartic acid) motif in coxsackievirus A9 has been implicated in internalization through an interaction with the integrin alpha v beta 3. We have produced a number of virus mutants, lacking the motif, which have a small-plaque phenotype in LLC-Mk2 and A-Vero cells and are phenotypically normal in RD cells. Substitution of flanking amino acids also affected plaque size. The results suggest...

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Identifiers

PMID: 7494317
DOI: 10.1128/JVI.69.12.8035-8040.1995
PMCID: PMC189749

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