Article
The coxsackievirus A9 RGD motif is not essential for virus viability.
Journal of virology - 1 Dec 1995
Hughes P J, Horsnell C, Hyypiä T, Stanway G
Abstract excerpt
An RGD (arginine-glycine-aspartic acid) motif in coxsackievirus A9 has been implicated in internalization through an interaction with the integrin alpha v beta 3. We have produced a number of virus mutants, lacking the motif, which have a small-plaque phenotype in LLC-Mk2 and A-Vero cells and are...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Chlorocebus aethiops
- DNA, Complementary
- Enterovirus
- Kinetics
- Molecular Sequence Data
- Mutagenesis
- Oligodeoxyribonucleotides
- Oligopeptides
- Phenotype
- Receptors, Vitronectin
- Sequence Deletion
- Vero Cells
- Viral Plaque Assay