Article
Psychophysical evaluation of cochlear hair cell damage due to the A3243G mitochondrial DNA mutation.
Journal of the Association for Research in Otolaryngology : JARO - 1 Jun 2001
Griffiths T D, Blakemore S, Elliott C, Moore B C, Chinnery P F
Abstract excerpt
Mitochondrial dysfunction is an important cause of human deafness, implicated in genetic deafness, toxin and noise damage. We assessed the mechanism of cochlear dysfunction in a population of 11 subjects with a specific mitochondrial disorder caused by the A3243G mitochondrial DNA mutation. Psychophysical tests were carried out to assess the inner and outer hair cell functions in vivo. Inner hair cell function...
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