Article
Abnormal organogenesis in salivary gland development may initiate adult onset of autoimmune exocrinopathy.
Experimental and clinical immunogenetics - 1 Jan 2001
Cha S, van Blockland S C, Versnel M A, Homo-Delarche F, Nagashima H, Brayer J, Peck A B, Humphreys-Beher M G
Abstract excerpt
OBJECTIVES: Salivary gland organogenesis was evaluated in NOD mice, an animal model for autoimmune exocrinopathy, to determine when disease onset is first present in the target tissues. METHODS: Submandibular glands were removed for histological, immunohistochemical and biochemical evaluation from neonatal NOD and congenic strains as well as healthy control C57BL/6 mice. RESULTS: Histomorphological analyses of...
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