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Article

Wobble modification defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease.

The EMBO journal - 3 Sept 2001

Yasukawa T, Suzuki T, Ishii N, Ohta S, Watanabe K

Abstract excerpt

We previously showed that in mitochondrial tRNA(Lys) with an A8344G mutation responsible for myoclonus epilepsy associated with ragged-red fibers (MERRF), a subgroup of mitochondrial encephalomyopathic diseases, the normally modified wobble base (a 2-thiouridine derivative) remains unmodified. Since wobble base modifications are essential for translational efficiency and accuracy, we used mitochondrial components...

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Share to MELAS Syndrome
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11532943
DOI: 10.1093/emboj/20.17.4794
PMCID: PMC125593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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