Article
Angiotensin-converting enzyme (ACE) I/D genotype and renal ACE gene expression.
Kidney international - 1 Sept 2001
Mizuiri S, Hemmi H, Kumanomidou H, Iwamoto M, Miyagi M, Sakai K, Aikawa A, Ohara T, Yamada K, Shimatake H, Hasegawa A
Abstract excerpt
BACKGROUND: The angiotensin-converting enzyme (ACE) I/D genotype affects serum ACE levels and the onset and progression of renal disease, but little is known about the mechanism. We investigated a possible association between the ACE I/D genotype and renal ACE mRNA levels in healthy subjects. METHODS: Renal biopsy samples were obtained from 50 healthy kidney donors. The ACE I/D genotype was determined by...
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