Article
Evaluating the Feasibility of DNA Methylation Analyses Using Long-Term Archived Brain Formalin-Fixed Paraffin-Embedded Samples.
Molecular neurobiology - 1 Jan 2018
Bak Stine T, Staunstrup Nicklas H, Starnawska Anna, Daugaard Tina F, Nyengaard Jens R, Nyegaard Mette, Børglum Anders, Mors Ole, Dorph-Petersen Karl-Anton, Nielsen Anders L
Abstract excerpt
We here characterize the usability of archival formalin-fixed paraffin-embedded (FFPE) brain tissue as a resource for genetic and DNA methylation analyses with potential relevance for brain-manifested diseases. We analyzed FFPE samples from The Brain Collection, Aarhus University Hospital Risskov, Denmark (AUBC), constituting 9479 formalin-fixated brains making it one of the largest collections worldwide. DNA...
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