Article
Analysis of an essential requirement for the poly(A) binding protein function using cross-species complementation.
Current biology : CB - 7 Aug 2001
Chekanova J A, Shaw R J, Belostotsky D A
Abstract excerpt
Poly(A) binding protein (PABP) is an essential, well-conserved, multifunctional protein involved in translational initiation, mRNA biogenesis, and degradation [1--5]. We have used a cross-species complementation approach to address the nature of the essential requirement for PABP in yeast. The expression of Pab3p, a member of the Arabidopsis thaliana PABP multigene family, rescues the lethal phenotype associated...
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