Article
A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders.
Cell - 10 Aug 2001
Gratacòs M, Nadal M, Martín-Santos R, Pujana M A, Gago J, Peral B, Armengol L, Ponsa I, Miró R, Bulbena A, Estivill X
Abstract excerpt
Anxiety disorders are complex and common psychiatric illnesses associated with considerable morbidity and social cost. We have studied the molecular basis of the cooccurrence of panic and phobic disorders with joint laxity. We have identified an interstitial duplication of human chromosome 15q24-26 (named DUP25), which is significantly associated with panic/agoraphobia/social phobia/joint laxity in families, and...
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