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Article

Induction of the Transcriptional Repressor Yin Yang-1 by Vascular Cell Injury

1 Nov 2001

Abstract excerpt

Yin Yang-1 (YY1) is a multifunctional transcription factor that can repress the expression of many growth factor, hormone, and cytokine genes implicated in atherogenesis. YY1 expression is activated in rat vascular smooth muscle cells shortly after injury. YY1 DNA binding activity paralleled elevated protein levels in the nucleus. Smooth muscle cell injury triggered the rapid extracellular release of...

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PMID: 11487577
DOI: 10.1074/jbc.m104913200

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