Article
Decreased platelet glutamate uptake and genetic risk factors in patients with Parkinson's disease.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Feb 2001
Ferrarese C, Tremolizzo L, Rigoldi M, Sala G, Begni B, Brighina L, Ricci G, Albizzati M G, Piolti R, Crosti F, Dalprà L, Frattola L
Abstract excerpt
Genetic risk factors seem to play a role in sporadic Parkinson's disease (PD), maybe triggering oxidative stress and excitotoxicity within substantia nigra. However, genetic factors act at systemic level: reduced activity of mitochondrial enzymes and decreased glutamate uptake have been shown in platelets from PD patients. In this study we investigated glutamate uptake in platelets from 38 sporadic PD patients,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.