Article
Variant transthyretin in blood circulation can transverse the blood-cerebrospinal barrier: qualitative analyses of transthyretin metabolism in sequential liver transplantation.
Transplantation - 27 Jul 2001
Terazaki H, Ando Y, Nakamura M, Obayashi K, Misumi S, Shoji S, Yamashita S, Nakagawa K, Ishizaki T, Suhr O, Uemoto S, Inomata Y, Tanaka K
Abstract excerpt
BACKGROUND: Although the choroid6 plexus of the brain is one of the most important production sites of transthyretin (TTR), the metabolism of TTR secreted in cerebrospinal fluid (CSF) remains to be elucidated. METHODS: To perform qualitative analysis of variant TTR in CSF of patients who underwent a sequential liver transplantation using an explanted familial amyloidotic polyneuropathy (FAP) ATTR Val30 Met...
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