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Article

Contribution of wild-type transthyretin to hereditary peripheral nerve amyloid.

Muscle & nerve - 1 Oct 2003

Yazaki Masahide, Liepnieks Juris J, Kincaid John C, Benson Merrill D

Abstract excerpt

To elucidate the contribution of wild-type transthyretin (TTR) to amyloid polyneuropathy in TTR amyloidosis, we biochemically investigated amyloid fibrils isolated from sciatic nerve of an autopsied patient with TTR Ala25Ser variant and compared the amount of wild-type and variant TTR in the nerve to that in the heart. Amyloid subunit protein from isolated fibrils was solubilized in 6M guanidine HCl and purified...

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Source

Identifiers

PMID: 14506715
DOI: 10.1002/mus.10452

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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