[Influence of genetic and environmental factors on lipid metabolism and cardiovascular risk associated with the apoE gene].

doi:10.1157/13092316

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Article

[Influence of genetic and environmental factors on lipid metabolism and cardiovascular risk associated with the apoE gene].

Medicina clinica - 9 Sept 2006

Moreno Juan Antonio, López-Miranda José, Pérez-Jiménez Francisco

Abstract excerpt

The apolipoprotein E (ApoE) plays an important role in lipid metabolism. This apoprotein presents three major isoforms (apoE2, apoE3 and apoE4) that modulate lipid levels. Carriers of the apoE4 allele have higher total and LDL-cholesterol plasma concentration and a greater coronary risk, particularly for myocardial infarction. Nevertheless, not all the people with this allele develop the disease, which suggests...

Topics

Apolipoproteins E
Cardiovascular Diseases
Clinical Trials as Topic
Genetic Predisposition to Disease
Genotype
Humans
Lipid Metabolism
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 16987455
DOI: 10.1157/13092316

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