Article
Development of ligase-assisted spacer addition for the measurement of microsatellites.
BioTechniques - 1 Jul 2001
Brockhurst V, Barnard R, Wolter L, Giffard P, Timms P
Abstract excerpt
Conventional methods for detecting differences in microsatellite repeat lengths rely on electrophoretic fractionation on long denaturing polyacrylamide gels, a time-consuming and labor-intensive method. Therefore, there is a need for the development of new and rapid approaches to routinely detect such length polymorphisms. The advent of techniques allowing the coupling of DNA molecules to solid surfaces has...
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