Article
Thrombogenic alleles, Escherichia coli O157:H7 infections, and hemolytic uremic syndrome.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jun 2001
Sprouse J T, Wong C S, Chandler W L, Williams G D, Watkins S L, Tarr P I
Abstract excerpt
Hemolytic uremic syndrome (HUS) of childhood most commonly follows gastrointestinal infection with Escherichia coli O157:H7. This pathogen elaborates Shiga toxins that are believed to cause microvascular injury and to trigger a thrombogenic response. The exact mechanisms leading to variable disease manifestations are unknown. Allelic variation in genes encoding selected coagulation factors and inhibitors of...
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