Substrate flow in catalases deduced from the crystal structures of active site variants of HPII from Escherichia coli.

Abstract excerpt

The active site of heme catalases is buried deep inside a structurally highly conserved homotetramer. Channels leading to the active site have been identified as potential routes for substrate flow and product release, although evidence in support of this model is limited. To investigate further the role of protein structure and molecular channels in catalysis, the crystal structures of four active site variants...

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