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Article

Familial influence on age of onset among siblings with Huntington disease*

23 May 2001

Abstract excerpt

In order to provide data relevant to a search for modifying genes for age of onset in Huntington disease, we examined the relationship between CAG number and age of onset in a total of 370 individuals from 165 siblingships, in two cohorts of siblings with Huntington disease: an American group of 144 individuals from 64 siblingships, and a Canadian population of 255 individuals from 113 siblingships. Using a...

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PMID: 11449389
DOI: 10.1002/ajmg.1400

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