Article
A polymorphic dinucleotide repeat in the rat nucleolin gene forms Z-DNA and inhibits promoter activity.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2001
Rothenburg S, Koch-Nolte F, Rich A, Haag F
Abstract excerpt
Many sequences in eukaryotic genomes have the potential to adopt a left-handed Z-DNA conformation. We used a previously described assay based on the binding of a mAb to Z-DNA to inquire whether Z-DNA is formed in the rat nucleolin (Ncl) gene in metabolically active, permeabilized nuclei. Using real-time PCR to measure Z-DNA formation, the potential Z-DNA sequence element Z1 [(CA)(10)(CG)(8)] in the promoter...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.