Article
Complex karyotype and absence of mutation in the c-kit receptor in aggressive mastocytosis presenting with pelvic osteolysis, eosinophilia and brain damage.
Annals of hematology - 1 May 2001
Jost E, Michaux L, Vanden Abeele M, Boland B, Latinne D, Godfraind C, Scheiff J M, Vaerman J L, Lecouvet F, Ferrant A
Abstract excerpt
Aggressive mastocytosis is a form of systemic mast cell disease (SMCD) characterized by organ infiltration, bone lesions. eosinophilia and lymphadenopathies. Here we report a patient with unusual clinical features, namely osteolysis without other bone lesions commonly found in SMCD, major eosinophilia and cerebral infarction. The mast cells exhibited a classical immunophenotype (CD2+, CD9+, CD13+, CD25+, CD35+,...
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