Article
A mutation in Bruton's tyrosine kinase as a cause of selective anti-polysaccharide antibody deficiency.
The Journal of pediatrics - 1 Jul 2001
Wood P M, Mayne A, Joyce H, Smith C I, Granoff D M, Kumararatne D S
Abstract excerpt
Children and adults can have recurrent infection with invasive encapsulated bacterial pathogens such as Streptococcus pneumoniae as a result of a selective inability to respond to polysaccharide antigens. We have identified a mutation in the gene encoding Bruton's tyrosine kinase in a male patient with selective anti-polysaccharide antibody deficiency.
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