Article
Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant.
The Journal of pathology - 1 Jul 2001
Rocha A S, Soares P, Seruca R, Máximo V, Matias-Guiu X, Cameselle-Teijeiro J, Sobrinho-Simões M
Abstract excerpt
The cadherin/catenin complex regulates cellular adhesion and motility and is believed to function as an invasion suppressor system. Several studies have identified alterations in the expression profiles of those molecules in different histotypes of thyroid carcinoma. The diffuse sclerosing variant (DSV) of papillary thyroid carcinoma (PTC) is a rare, highly invasive variant of PTC in which an impairment of...
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