Article
Systematic screening for mutations in the human necdin gene (NDN): identification of two naturally occurring polymorphisms and association analysis in body weight regulation.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Jun 2001
Oeffner F, Korn T, Roth H, Ziegler A, Hinney A, Goldschmidt H, Siegfried W, Hebebrand J, Grzeschik K H
Abstract excerpt
BACKGROUND: NDN, which codes for the human necdin protein, is a candidate gene for Prader-Willi syndrome (PWS). One feature of this neurogenetic disorder is hyperphagia resulting in extreme obesity observed later in development. OBJECTIVE AND DESIGN: In this study we have used single-strand conformation polymorphism (SSCP) analysis to identify sequence variants at the human necdin gene. Furthermore we tested...
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