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Article

A mouse model for adenovirus gene delivery

3 Jul 2001

Abstract excerpt

The cellular attachment receptor for adenovirus (Ad), Coxsackie adenovirus receptor (CAR), required for delivery of Ad into primary cells, is not present on all cell types, thus restricting Ad-gene delivery systems. To circumvent this constrain, a transgenic mouse has been generated that expresses a truncated human CAR in all tissues analyzed. These mice allowed efficient in vitro infections at low multiplicities...

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PMID: 11438737
DOI: 10.1073/pnas.141223398

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