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cAMP-INDUCED APOPTOSIS IN GRANULOSA CELLS IS ASSOCIATED WITH UP-REGULATION OF P53 AND BAX AND DOWN-REGULATION OF CLUSTERIN

1 Jan 2001

Abstract excerpt

Evidence indicates that cAMP induces apoptosis in granulosa cells of rat and human ovary. The mechanism by which cAMP induces apoptosis is not known. This study was carried out to evaluate changes in expression of cell death promoters, P53 and bax, and cell death repressor, bcl-2, in cAMP-treated granulosa cells. Treatment of granulosa cells with forskolin (FSK), or 8-bromo-cAMP induced apoptosis as evidenced by...

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Identifiers

PMID: 11428715
DOI: 10.1081/erc-100107184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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