Article
Diagnosis of human parvovirus B19 infections by detection of epitope-type-specific VP2 IgG.
Journal of medical virology - 1 Jul 2001
Kaikkonen L, Söderlund-Venermo M, Brunstein J, Schou O, Panum Jensen I, Rousseau S, Caul E O, Cohen B, Valle M, Hedman L, Hedman K
Abstract excerpt
In the B19 VP2 molecule an immunodominant heptapeptide epitope has been detected, recently for which IgG antibodies are synthesized exclusively in the acute phase of B19 infection. Using this acute-phase-specific epitope (KYVTGIN) a 2(nd)-generation epitope-type EIA was developed, which compares serum IgG activity for native VP2 capsids exhibiting conformational VP2 epitopes with IgG activity for the KYVTGIN...
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