Article
A protein antibiotic in the phage Qbeta virion: diversity in lysis targets.
Science (New York, N.Y.) - 22 Jun 2001
Bernhardt T G, Wang I N, Struck D K, Young R
Abstract excerpt
A(2), a capsid protein of RNA phage Qbeta, is also responsible for host lysis. A(2) blocked synthesis of murein precursors in vivo by inhibiting MurA, the catalyst of the committed step of murein biosynthesis. An A(2)-resistance mutation mapped to an exposed surface near the substrate-binding cleft of MurA. Moreover, purified Qbeta virions inhibited wild-type MurA, but not the mutant MurA, in vitro. Thus, the two...
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