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Article

RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio cholerae.

Nature communications - 27 Nov 2020

Peschek Nikolai, Herzog Roman, Singh Praveen K, Sprenger Marcel, Meyer Fabian, Fröhlich Kathrin S, Schröger Luise, Bramkamp Marc, Drescher Knut, Papenfort Kai

Abstract excerpt

Vibrio cholerae, the cause of cholera disease, exhibits a characteristic curved rod morphology, which promotes infectivity and motility in dense hydrogels. Periplasmic protein CrvA determines cell curvature in V. cholerae, yet the regulatory factors controlling CrvA are unknown. Here, we discover the VadR small RNA (sRNA) as a post-transcriptional inhibitor of the crvA mRNA. Mutation of vadR increases cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33247102
DOI: 10.1038/s41467-020-19890-8
PMCID: PMC7695739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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