Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia.

Leukemia - 1 Jun 2001

Lezon-Geyda K, Najfeld V, Johnson E M

Abstract excerpt

Deletions or monosomy of chromosomes 5 and 7 are frequently observed in myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML). In this study two genes, PURA and PURB, encoding functionally cooperative proteins in the Pur family, are localized to chromosome bands 5q31.1 and 7p13, respectively. One or both of these loci are shown to be hemizygously deleted in 60 MDS or AML patients using fluorescence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Artificial, Bacterial
Share to Chromosomes, Human, Pair 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 7

Share to Cyclic AMP Response Element-Binding Protein

Share to Early Growth Response Protein 1

Share to Immediate-Early Proteins

Share to Leukemia, Myeloid

Share to Myelodysplastic Syndromes

Source

Identifiers

PMID: 11417483
DOI: 10.1038/sj.leu.2402108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia.PMID 11417483Read ↗

The pur protein family: Genetic and structural features in development and diseaseSemantic proximity Read ↗

Narrowing and genomic annotation of the commonly deleted region of the 5q− syndromeSemantic proximity Read ↗

FISH and SNP-A karyotyping in myelodysplastic syndromes: improving cytogenetic detection of del(5q), monosomy 7, del(7q), trisomy 8 and del(20q).Semantic proximity Read ↗

SURVEY AND SUMMARY: Puralpha: a multifunctional single-stranded DNA- and RNA-binding proteinSemantic proximity Read ↗

Molecular cytogenetic delineation of the critical deleted region in the 5q− syndromeSemantic proximity Read ↗

PURA , the gene encoding Pur-alpha, member of an ancient nucleic acid-binding protein family with mammalian neurological functionsSemantic proximity Read ↗

Molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases to 1–1.5 Mb and preparation of a PAC-based physical mapSemantic proximity Read ↗

Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcriptsSemantic proximity Read ↗

Molecular Cytogenetic Delineation of Deletions and Translocations Involving Chromosome Band 7q22 in Myeloid LeukemiasSemantic proximity Read ↗

Molecular definition of chromosome arm 5q deletion end points and detection of hidden aberrations in patients with myelodysplastic syndromes and isolated del(5q) using oligonucleotide array CGHSemantic proximity Read ↗

Lenalidomide inhibits the malignant clone and up-regulates the <i>SPARC</i> gene mapping to the commonly deleted region in 5q− syndrome patientsSemantic proximity Read ↗

Molecular Cytogenetic Characterization of a Critical Region in Bands 7q35-q36 Commonly Deleted in Malignant Myeloid DisordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.