Article
Clonal composition of pituitary adenomas in patients with Cushing's disease: determination by X-chromosome inactivation analysis.
The Journal of clinical endocrinology and metabolism - 1 Dec 1991
Schulte H M, Oldfield E H, Allolio B, Katz D A, Berkman R A, Ali I U
Abstract excerpt
The synthesis and secretion of anterior pituitary hormones are subjected to a variety of positive and negative feedback mechanisms. Aberrancies of these highly regulated phenomena may lead to hyperplasia involving multiple cells of the anterior lobe. Alternatively, a rare genetic mutation in a single cell may precede its clonal expansion. Which of these mechanisms is operative in the development of corticotroph...
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