Article
Clonal composition of pituitary adenomas in patients with Cushing's disease: determination by X-chromosome inactivation analysis.
The Journal of clinical endocrinology and metabolism - 1 Dec 1991
Schulte H M, Oldfield E H, Allolio B, Katz D A, Berkman R A, Ali I U
Abstract excerpt
The synthesis and secretion of anterior pituitary hormones are subjected to a variety of positive and negative feedback mechanisms. Aberrancies of these highly regulated phenomena may lead to hyperplasia involving multiple cells of the anterior lobe. Alternatively, a rare genetic mutation in a si...
Topics
- Adenoma
- Alleles
- Antigens, CD
- Clone Cells
- Cushing Syndrome
- DNA
- Female
- Heterozygote
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Phosphoglycerate Kinase
- Pituitary Hormones
- Pituitary Neoplasms
- Polymorphism, Restriction Fragment Length
- Staining and Labeling
- X Chromosome