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The Hemagglutinin of Canine Distemper Virus Determines Tropism and Cytopathogenicity

15 Jul 2001

Abstract excerpt

Canine distemper virus (CDV) and measles virus (MV) cause severe illnesses in their respective hosts. The viruses display a characteristic cytopathic effect by forming syncytia in susceptible cells. For CDV, the proficiency of syncytium formation varies among different strains and correlates with the degree of viral attenuation. In this study, we examined the determinants for the differential fusogenicity of the...

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PMID: 11413309
DOI: 10.1128/jvi.75.14.6418-6427.2001

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