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Article

Human GC-AG alternative intron isoforms with weak donor sites show enhanced consensus at acceptor exon positions.

Nucleic acids research - 15 Jun 2001

Thanaraj T A, Clark F

Abstract excerpt

It has been previously observed that the intrinsically weak variant GC donor sites, in order to be recognized by the U2-type spliceosome, possess strong consensus sequences maximized for base pair formation with U1 and U5/U6 snRNAs. However, variability in signal strength is a fundamental mechanism for splice site selection in alternative splicing. Here we report human alternative GC-AG introns (for the first...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11410667
DOI: 10.1093/nar/29.12.2581
PMCID: PMC55748

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Source receipt: pubmed, retrieved 7 Sept 2026.

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