Article
Metabolism of styrene in the human liver in vitro: interindividual variation and enantioselectivity.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Feb 2001
Wenker M A, Kezić S, Monster A C, De Wolff F A
Abstract excerpt
1. The interindividual variation and enantioselectivity of the in vitro styrene oxidation by cytochrome P450 have been investigated in 20 human microsomal liver samples. Liver samples were genotyped for the CYP2E1*6 and CYP2E1*5B alleles. 2. Kinetic analysis indicated the presence of at least two forms of styrene-metabolizing cytochrome P450. The enzyme constants for the high-affinity component were subject to...
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