Article
p53 Pseudogene dating: identification of the origin of laboratory mice.
Gene - 30 May 2001
Tanooka H, Sasaki H, Shiroishi T, Moriwaki K
Abstract excerpt
Mutations were accumulated with a wide variety in the p53 pseudogene of various wild mouse species and subspecies captured at different localities, as extensively observed in the exon 4 - exon 5 region. The rate of mutation accumulation in the mouse p53 pseudogene was estimated to be 1.4-2.1x10(-8) mutations/bp/year, which is 20-30 times faster than that of the functional p53 and makes the dating possible for the...
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