Article
Ras regulation of vascular endothelial growth factor and angiogenesis.
Methods in enzymology - 1 Jan 2001
Rak J, Kerbel R S
Abstract excerpt
Given the multifaceted role of Ras in tumor angiogenesis, pharmacologic targeting of such proteins may bring about at least three important consequences: (1) partial obliteration of the angiogenic competence of tumor cells, (2) an increase in vascular dependence and sensitization to apoptosis, and (3) a direct inhibition of endothelial cell responses to proangiogenic stimuli. Exploration of some of these...
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