Article
The contribution of intraabdominal fat to gender differences in hepatic lipase activity and low/high density lipoprotein heterogeneity.
The Journal of clinical endocrinology and metabolism - 1 Jun 2001
Carr M C, Hokanson J E, Zambon A, Deeb S S, Barrett P H, Purnell J Q, Brunzell J D
Abstract excerpt
Hepatic lipase (HL) hydrolyzes triglyceride and phospholipid in low and high density lipoprotein cholesterol (LDL-C and HDL-C, respectively), and elevated HL activity is associated with small, dense atherogenic LDL particles and reduced HDL2-C. Elevated HL activity is associated with increasing age, male gender, high amounts of intraabdominal fat (IAF), and the HL gene (LIPC) promoter polymorphism (C nucleotide...
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