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Article

The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design.

Archives of biochemistry and biophysics - 15 Jun 2001

Velazquez-Campoy A, Kiso Y, Freire E

Abstract excerpt

KNI-764 is a powerful HIV-1 protease inhibitor with a reported low susceptibility to the effects of protease mutations commonly associated with drug resistance. In this paper the binding thermodynamics of KNI-764 to the wild-type and drug-resistant mutant V82F/I84V are presented and the results compared to those obtained with existing clinical inhibitors. KNI-764 binds to the wild-type HIV-1 protease with very...

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Source

Identifiers

PMID: 11396919
DOI: 10.1006/abbi.2001.2333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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